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1

Molecular mechanisms of the antagonistic action between AT1 and AT2 receptors

Shin-ichiro Miura, Yoshino Matsuo, Yoshihiro Kiya, Sadashiva S. Karnik, Keijiro Saku

Journal:

Biochemical and Biophysical Research Communications

Year:

2010

Language:

english

File:

PDF, 391 KB

english, 2010

2

Activation of G-protein-coupled receptors: a common molecular mechanism

Sadashiva S. Karnik, Camelia Gogonea, Supriya Patil, Yasser Saad, Takanobu Takezako

Journal:

Trends in Endocrinology & Metabolism

Year:

2003

Language:

english

File:

PDF, 414 KB

english, 2003

3

Domain coupling in GPCRs: the engine for induced conformational changes

Hamiyet Unal, Sadashiva S. Karnik

Journal:

Trends in Pharmacological Sciences

Year:

2012

Language:

english

File:

PDF, 1.00 MB

english, 2012

4

There is no overkill in biochemistry

Karnik, Sadashiva, Subramaniam, Sriram

Journal:

Year:

2012

Language:

english

File:

PDF, 217 KB

english, 2012

5

Significance of angiotensin 1-7 coupling with MAS1 receptor and other GPCRs to the renin-angiotensin system: IUPHAR Review 22

Karnik, Sadashiva S, Singh, Khuraijam Dhanachandra, Tirupula, Kalyan, Unal, Hamiyet

Journal:

British Journal of Pharmacology

Year:

2017

Language:

english

File:

PDF, 851 KB

english, 2017

6

Transfection ofMycobacterium smegmatisSN2 with mycobacteriophage I3 DNA

S. Sadashiva Karnik, K. P. Gopinathan

Journal:

Archives of Microbiology

Year:

1983

Language:

english

File:

PDF, 560 KB

english, 1983

7

Presence of nucleoside triphosphates and calcium associated with mycobacteriophage I3

S. Sadashiva Karnik, K. P. Gopinathan

Journal:

Archives of Microbiology

Year:

1981

Language:

english

File:

PDF, 366 KB

english, 1981

8

Model of the whole rat AT1receptor and the ligand-binding site

Camelia Baleanu-Gogonea, Sadashiva Karnik

Journal:

Journal of Molecular Modeling

Year:

2006

Language:

english

File:

PDF, 730 KB

english, 2006

9

A protein tyrosine phosphatase inhibitor, pervanadate, inhibits angiotensin II-Induced β-arrestin cleavage

Sei-Heon Jang, Si Ae Hwang, Mijin Kim, Sung-Hae Yun, Moon-Sook Kim, Sadashiva S. Karnik, ChangWoo Lee

Journal:

Molecules and Cells

Year:

2009

Language:

english

File:

PDF, 401 KB

english, 2009

10

MicroRNAs—Regulators of Signaling Networks in Dilated Cardiomyopathy

Sathyamangla V. Naga Prasad, Sadashiva S. Karnik

Journal:

Journal of Cardiovascular Translational Research

Year:

2010

Language:

english

File:

PDF, 454 KB

english, 2010

11

Proceedings of the Symposium ‘Angiotensin AT1 Receptors: From Molecular Physiology to Therapeutics’: MOLECULAR DETERMINANTS OF PEPTIDE AND NON-PEPTIDE BINDING TO THE AT1 RECEPTOR

Sadashiva S Karnik, Ahsan Husain, Professor Robert M Graham

Journal:

Clinical and Experimental Pharmacology and Physiology

Year:

1996

Language:

english

File:

PDF, 926 KB

english, 1996

12

Thymidine phosphorylase inhibits vascular smooth muscle cell proliferation via upregulation of STAT3

Hong Yue, Kuniyoshi Tanaka, Tatsuhiko Furukawa, Sadashiva S. Karnik, Wei Li

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Year:

2012

Language:

english

File:

PDF, 525 KB

english, 2012

13

Manifold active-state conformations in GPCRs: Agonist-activated constitutively active mutant AT1 receptor preferentially couples to Gq compared to the wild-type AT1 receptor

ChangWoo Lee, Si Ae Hwang, Sei-Heon Jang, Hye-Shin Chung, Manjunatha B. Bhat, Sadashiva S. Karnik

Journal:

Year:

2007

Language:

english

File:

PDF, 297 KB

english, 2007

14

Angiotensinergic stimulation of vascular endothelium in mice causes hypotension, bradycardia and attenuated angiotensin response

Takanobu Takezako, Ramaswamy Ramchandran, Yasser Saad, Naoki Makino, Sadashiva S. Karnik

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2008

Language:

english

File:

PDF, 47 KB

english, 2008

15

Angiotensin II type 1 receptor-function affected by mutations in cytoplasmic loop CD

Shin-ichiro Miura, Jingli Zhang, Sadashiva S Karnik

Journal:

Year:

2000

Language:

english

File:

PDF, 155 KB

english, 2000

16

Reversible inactivation of AT2 angiotensin II receptor from cysteine–disulfide bond exchange

Ying-Hong Feng, Yasser Saad, Sadashiva S Karnik

Journal:

Year:

2000

Language:

english

File:

PDF, 274 KB

english, 2000

17

Circulating and tissue angiotensin II type 1 receptors from perioperation through one-year of transplantation: A potential molecular mechanism for cardiac allograft vasculopathy

Mohammed Yousufuddin, Randall C. Starling, E. Murat Tuzcu, Ashraf Abdo, Philip Paul, Showkat Haji, Norman B. Ratliff, Daniel J. Cook, Yasser Saad, Sadashiva Karnik, Patrick M. McCarthy, James B. Young

Journal:

Journal of the American College of Cardiology

Year:

2003

Language:

english

File:

PDF, 371 KB

english, 2003

18

Design of pH Sensitive Binding Proteins from the Hyperthermophilic Sso7d Scaffold

Gera, Nimish, Hill, Andrew B., White, Dalon P., Carbonell, Ruben G., Rao, Balaji M., Karnik, Sadashiva

Journal:

Year:

2012

Language:

english

File:

PDF, 1.95 MB

english, 2012

19

G-Protein-Dependent Cell Surface Dynamics of the Human Serotonin 1A Receptor Tagged to Yellow Fluorescent Protein †

Pucadyil, Thomas J., Kalipatnapu, Shanti, Harikumar, Kaleeckal G., Rangaraj, Nandini, Karnik, Sadashiva S., Chattopadhyay, Amitabha

Journal:

Year:

2004

Language:

english

File:

PDF, 415 KB

english, 2004

20

Clinical and Pharmacotherapeutic Relevance of the Double-Chain Domain of the Angiotensin II Type 1 Receptor Blocker Olmesartan

Kiya, Yoshihiro, Miura, Shin-Ichiro, Fujino, Masahiro, Imaizumi, Satoshi, Karnik, Sadashiva S., Saku, Keijiro

Journal:

Clinical and Experimental Hypertension

Year:

2010

Language:

english

File:

PDF, 404 KB

english, 2010

21

Unique binding behavior of the recently approved angiotensin II receptor blocker azilsartan compared with that of candesartan

Miura, Shin-ichiro, Okabe, Atsutoshi, Matsuo, Yoshino, Karnik, Sadashiva S, Saku, Keijiro

Journal:

Hypertension Research

Year:

2013

Language:

english

File:

PDF, 682 KB

english, 2013

22

Total Synthesis of a Gene for Bovine Rhodopsin

Luca Ferretti, Sadashiva S. Karnik, H. Gobind Khorana, Michael Nassal and Daniel D. Oprian

Journal:

Proceedings of the National Academy of Sciences

Year:

1986

Language:

english

File:

PDF, 1.20 MB

english, 1986

23

Cysteine Residues 110 and 187 are Essential for the Formation of Correct Structure in Bovine Rhodopsin

Sadashiva S. Karnik, Thomas P. Sakmar, Hai-Bao Chen and H. Gobind Khorana

Journal:

Proceedings of the National Academy of Sciences

Year:

1988

Language:

english

File:

PDF, 1.07 MB

english, 1988

24

Angiotensin II-regulated microRNA 483-3p directly targets multiple components of the renin–angiotensin system

Kemp, Jacqueline R., Unal, Hamiyet, Desnoyer, Russell, Yue, Hong, Bhatnagar, Anushree, Karnik, Sadashiva S.

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2014

Language:

english

File:

PDF, 2.14 MB

english, 2014

25

The Active State of the AT 1 Angiotensin Receptor Is Generated by Angiotensin II Induction †

Noda, Keita, Feng, Ying-Hong, Liu, Xiao-pu, Saad, Yasser, Husain, Ahsan, Karnik, Sadashiva S.

Journal:

Year:

1996

Language:

english

File:

PDF, 373 KB

english, 1996

26

Mechanism of Constitutive Activation of the AT 1 Receptor: Influence of the Size of the Agonist Switch Binding Residue Asn 111†

Feng, Ying-Hong, Miura, Shin-ichiro, Husain, Ahsan, Karnik, Sadashiva S.

Journal:

Year:

1998

Language:

english

File:

PDF, 99 KB

english, 1998

27

A small difference in the molecular structure of angiotensin II receptor blockers induces AT1 receptor-dependent and -independent beneficial effects

Fujino, Masahiro, Miura, Shin-ichiro, Kiya, Yoshihiro, Tominaga, Yukio, Matsuo, Yoshino, Karnik, Sadashiva S, Saku, Keijiro

Journal:

Hypertension Research

Year:

2010

Language:

english

File:

PDF, 830 KB

english, 2010

28

Critical Role for Lysine 685 in Gene Expression Mediated by Transcription Factor Unphosphorylated STAT3

Dasgupta, Maupali, Unal, Hamiyet, Willard, Belinda, Yang, Jinbo, Karnik, Sadashiva S., Stark, George R.

Journal:

Journal of Biological Chemistry

Year:

2014

Language:

english

File:

PDF, 1.70 MB

english, 2014

29

A Mechanism of Global Shape-dependent Recognition and Phosphorylation of Filamin by Protein Kinase A

Ithychanda, Sujay Subbayya, Fang, Xianyang, Mohan, Maradumane L., Zhu, Liang, Tirupula, Kalyan C., Naga Prasad, Sathyamangla V., Wang, Yun-Xing, Karnik, Sadashiva S., Qin, Jun

Journal:

Journal of Biological Chemistry

Year:

2015

Language:

english

File:

PDF, 3.27 MB

english, 2015

30

Differential Bonding Interactions of Inverse Agonists of Angiotensin II Type 1 Receptor in Stabilizing the Inactive State

Miura, Shin-ichiro, Kiya, Yoshihiro, Kanazawa, Takanori, Imaizumi, Satoshi, Fujino, Masahiro, Matsuo, Yoshino, Karnik, Sadashiva S., Saku, Keijiro

Journal:

Molecular Endocrinology

Year:

2008

Language:

english

File:

PDF, 262 KB

english, 2008

31

Reassessment of the Unique Mode of Binding between Angiotensin II Type 1 Receptor and Their Blockers

Miura, Shin-Ichiro, Nakao, Naoki, Hanzawa, Hiroyuki, Matsuo, Yoshino, Saku, Keijiro, Karnik, Sadashiva S., Seifert, Roland

Journal:

Year:

2013

Language:

english

File:

PDF, 1.28 MB

english, 2013

32

G protein-coupled receptors directly bind Filamin A with high-affinity and promote Filamin phosphorylation

Tirupula, Kalyan C, Ithychanda, Sujay Subbayya, Mohan, Maradumane L., Naga Prasad, Sathyamangla V., Qin, Jun, Karnik, Sadashiva S

Journal:

Year:

2015

Language:

english

File:

PDF, 1.98 MB

english, 2015

33

Structural Basis for Ligand Recognition and Functional Selectivity at Angiotensin Receptor

Zhang, Haitao, Unal, Hamiyet, Desnoyer, Russell, Han, Gye Won, Patel, Nilkanth, Katritch, Vsevolod, Karnik, Sadashiva S., Cherezov, Vadim, Stevens, Raymond C.

Journal:

Journal of Biological Chemistry

Year:

2015

Language:

english

File:

PDF, 1.90 MB

english, 2015

34

Palmitoylation of Bovine Opsin and Its Cysteine Mutants in COS Cells

Sadashiva S. Karnik, Kevin D. Ridge, Santanu Bhattacharya and H. Gobind Khorana

Journal:

Proceedings of the National Academy of Sciences

Year:

1993

Language:

english

File:

PDF, 1.04 MB

english, 1993

35

Angiotensin II type 1 and type 2 receptors bind angiotensin II through different types of epitope recognition

Miura, Shin-ichiro, Karnik, Sadashiva S.

Journal:

Journal of Hypertension

Year:

1999

Language:

english

File:

PDF, 253 KB

english, 1999

36

Expression of the Archaebacterial Bacterio-Opsin Gene With and Without Signal Sequences in Escherichia coli: The Expressed Proteins are Located in the Membrane but Bind Retinal Poorly

Sadashiva Karnik, Tomoko Doi, R. Molday and H. Gobind Khorana

Journal:

Proceedings of the National Academy of Sciences

Year:

1990

Language:

english

File:

PDF, 1.18 MB

english, 1990

37

Structure-Function Studies on Bacteriorhodopsin

Mogi, Tatsushi, Karnik, Sadashiva S, Khorana, H Gobind

Journal:

Journal of Biological Chemistry

Year:

1987

Language:

english

File:

PDF, 3.96 MB

english, 1987

38

Current topics in angiotensin II type 1 receptor research: Focus on inverse agonism, receptor dimerization and biased agonism

Takezako, Takanobu, Unal, Hamiyet, Karnik, Sadashiva S., Node, Koichi

Journal:

Pharmacological Research

Year:

2017

Language:

english

File:

PDF, 1.35 MB

english, 2017

39

Unique binding behavior of the recently approved angiotensin II receptor blocker azilsartan compared with that of candesartan

Miura, Shin-ichiro, Okabe, Atsutoshi, Matsuo, Yoshino, Karnik, Sadashiva S, Saku, Keijiro

Journal:

Hypertension Research

Year:

2013

Language:

english

File:

PDF, 138 KB

english, 2013

40

[Methods in Enzymology] G Protein Pathways Part A: Ribonucleases Volume 343 || Analysis of structure-function from expression of G protein-coupled receptor fragments

Karnik, Sadashiva S.

Year:

2002

Language:

english

File:

PDF, 911 KB

english, 2002

41

Divergent Spatiotemporal Interaction of Angiotensin Receptor Blocking Drugs with Angiotensin Type1 Receptor

Khuraijam, Dhanachandra Singh, Unal, Hamiyet, Desnoyer, Russell, Karnik, Sadashiva S

Journal:

Journal of Chemical Information and Modeling

Year:

2017

Language:

english

File:

PDF, 2.57 MB

english, 2017

42

The non-biphenyl-tetrazole AT1 receptor blocker eprosartan is a unique and robust inverse agonist of the active state of AT1 receptor

Takezako, Takanobu, Unal, Hamiyet, Karnik, Sadashiva S, Node, Koichi

Journal:

British Journal of Pharmacology

Year:

2018

Language:

english

File:

PDF, 1.05 MB

english, 2018

43

Primary prevention of myocardial infarction with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in hypertensive patients with rheumatoid arthritis—A nationwide cohort study

Lin, Ting-Tse, Wu, Cho-Kai, Liao, Min-Tsun, Yang, Yao-Hsu, Chen, Pau-Chung, Yeih, Dong-Feng, Lin, Lian-Yu, Karnik, Sadashiva S

Journal:

Year:

2017

Language:

english

File:

PDF, 2.04 MB

english, 2017

44

Small Molecules with Similar Structures Exhibit Agonist, Neutral Antagonist or Inverse Agonist Activity toward Angiotensin II Type 1 Receptor

Miura, Shin-ichiro, Kiya, Yoshihiro, Hanzawa, Hiroyuki, Nakao, Naoki, Fujino, Masahiro, Imaizumi, Satoshi, Matsuo, Yoshino, Yanagisawa, Hiroaki, Koike, Hiroyuki, Komuro, Issei, Karnik, Sadashiva S., S

Journal:

Year:

2012

Language:

english

File:

PDF, 2.45 MB

english, 2012

45

Maize Ribosome-Inactivating Protein Uses Lys158–Lys161 to Interact with Ribosomal Protein P2 and the Strength of Interaction Is Correlated to the Biological Activities

Wong, Yuen-Ting, Ng, Yiu-Ming, Mak, Amanda Nga-Sze, Sze, Kong-Hung, Wong, Kam-Bo, Shaw, Pang-Chui, Karnik, Sadashiva

Journal:

Year:

2012

Language:

english

File:

PDF, 632 KB

english, 2012

46

Transient and Stable Expression of the Neurotensin Receptor NTS1: A Comparison of the Baculovirus-Insect Cell and the T-REx-293 Expression Systems

Xiao, Su, White, Jim F., Betenbaugh, Michael J., Grisshammer, Reinhard, Shiloach, Joseph, Karnik, Sadashiva

Journal:

Year:

2013

Language:

english

File:

PDF, 970 KB

english, 2013

47

LHX3 Interacts with Inhibitor of Histone Acetyltransferase Complex Subunits LANP and TAF-1β to Modulate Pituitary Gene Regulation

Hunter, Chad S., Malik, Raleigh E., Witzmann, Frank A., Rhodes, Simon J., Karnik, Sadashiva

Journal:

Year:

2013

Language:

english

File:

PDF, 739 KB

english, 2013

48

Mechanical Stretch Increases MMP-2 Production in Vascular Smooth Muscle Cells via Activation of PDGFR-β/Akt Signaling Pathway

Seo, Kyo Won, Lee, Seung Jin, Kim, Yun Hak, Bae, Jin Ung, Park, So Youn, Bae, Sun Sik, Kim, Chi Dae, Karnik, Sadashiva

Journal:

Year:

2013

Language:

english

File:

PDF, 2.64 MB

english, 2013

49

Integrative Genetic Characterization and Phenotype Correlations in Pheochromocytoma and Paraganglioma Tumours

Crona, Joakim, Nordling, Margareta, Maharjan, Rajani, Granberg, Dan, Stålberg, Peter, Hellman, Per, Björklund, Peyman, Karnik, Sadashiva

Journal:

Year:

2014

Language:

english

File:

PDF, 452 KB

english, 2014

50

Significance of AT1 Receptor Independent Activation of Mineralocorticoid Receptor in Murine Diabetic Cardiomyopathy

Nagatomo, Yuji, Meguro, Tomomi, Ito, Hiroyuki, Koide, Kimi, Anzai, Toshihisa, Fukuda, Keiichi, Ogawa, Satoshi, Yoshikawa, Tsutomu, Karnik, Sadashiva

Journal:

Year:

2014

Language:

english

File:

PDF, 2.00 MB

english, 2014

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